Description
Product Characteristics:
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.
Subcellular location: Cytoplasm
Synonyms: Nucleoside diphosphate linked moiety X type motif 14, Nucleoside diphosphate-linked moiety X motif 14, NUD14_HUMAN, Nudix (nucleoside diphosphate linked moiety X) type motif 14, Nudix motif 14, NUDT14, UDP sugar diphosphatase, UDPG pyrophosphatase, UGPP, UGPPase, Uridine diphosphate glucose pyrophosphatase.
Target Information: UDP-glucose (UDPG) acts as the sugar donor in numerous glycosylation reactions, including those involved in the production of glycogen. NUDT14 is a UDPG pyrophosphatase (EC 3.6.1.45) that hydrolyzes UDPG to produce glucose 1-phosphate and UMP (Yagi et al., 2003 [PubMed 12429023]).[supplied by OMIM, Mar 2008]